Anthony Shum, M.D.

Associate Professor

Robert L. Kroc Chair in Rheumatic and Connective Tissue Diseases II

Anthony Shum is an Associate Professor of Medicine in the Department of Pulmonary and Critical Care at UCSF. After his clinical fellowship at UCSF, he received research training in immune tolerance as part of the Immunology Program at UCSF. The focus of his lab's research is to understand the pathogenesis of autoimmune lung diseases by intensively studying patients with these disorders and modeling their disease in mice. Through his work he identified a novel lung-specific antigen named BPIFB1 that is targeted in patients with autoimmune lung disease and demonstrated that autoantibodies to BPIFB1 could be used as a biomarker to detect patients with lung autoimmunity. His lab also recently helped discover the genetic basis of a novel Mendelian syndrome of autoimmunity manifested by lung and joint disease that is coined the COPA syndrome, based on the gene that is mutated in this disorder. Through his research Dr. Shum hopes to discover diagnostic and interventional targets that will ultimately lead to biomarkers and therapies that will directly impact patient care.

Zhenlu Chong, Ph.D.

Postdoctoral Fellow

Zhenlu is a postdoctoral fellow who joined Dr. Shum’s lab after graduating from the Institute of Immunology, School of Medicine, Zhejiang University. He worked on ubiquitination in regulating antiviral innate immune responses and autoimmune diseases during his PhD training. Now he is focusing on the physiological and pathological mechanisms of COPA Syndrome. Zhenlu is a passionate basketball fan and his favorite player is Chris Paul, aka CP3. Sometimes he also likes to play badminton. He loves noodles, dumplings, hot pot and all kinds of Chinese dishes.

Zimu Deng, Ph.D.

Postdoctoral Fellow

Zimu is a postdoctoral fellow who studies autoimmune disorders such as interstitial lung diseases through translational approaches. After graduating from the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences with a Ph.D. in cell biology and immunology, she joined the Shum lab with great enthusiasm to solve the COPA Syndrome. Zimu’s greatest interest is to understand how immunology shapes human diseases. In her free time she loves to read, sip tea in cat cafes, swim and try exotic foods.

Frances Ho

Lab Assistant

Christopher Law

Lab Manager

Chris is a founding member of the Shum lab who was recruited to help launch the research program. He has since expertly filled many roles: protein purifier, mouse designer, website builder, computer repairman, and many others. He serves as the lab manager and most importantly, fills in as the “hired gun” that is tasked with mastering the most difficult techniques and launching early projects forward. Chris earned his bachelor’s degree in Biochemistry and Molecular Biology at UC Davis and previously worked in the UCSF Diabetes Center with Dr. David Gardner on vitamin D dependent mechanisms of cardiovascular health. He is committed to the Shum lab mission of solving autoimmune lung diseases. In his free time, Chris enjoys photography, retro gaming, and spoiling his dog nephew, Teddy.

Carlos Castellanos

Graduate (Rotation) Student

Marissa Cazares

Lab Assistant

Oscar Estrada, M.D.

Clinical Instructor (UCLA)

Birthe Jessen, Ph.D.

Postdoctoral Fellow

Spencer Liu

Intern

Wint Lwin

Staff Research Associate

Shyam Srivats, Ph.D.

Postdoctoral Fellow

Jessica Tsui, M.D.

Clinical Fellow

Kristin Wang

Lab Assistant